A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruli

A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruli

Blog Article

Major histocompatibility class I Educational Toys (MHCI) molecules are well known for their immunological role in mediating tissue graft rejection.Recently, these molecules were discovered to be expressed in distinct neuronal subclasses, dispelling the long-held tenet that the uninjured brain is immune-privileged.Here, we show that MHCI molecules are expressed in the main olfactory bulb (MOB) of adult animals.

Furthermore, we find that mice with diminished levels of MHCI expression have Cord enlarged MOBs containing an increased number of small, morphologically abnormal and ectopically located P2 glomeruli.These findings suggest that MHCI molecules may play an important role in the proper formation of glomeruli in the bulb.